SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts
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چکیده
منابع مشابه
Molecular Characterization and Tissue-specific Expression of a Novel FKBP38 Gene in the Cashmere Goat (Capra hircus)
As a member of a subclass of immunophilins, it is controversial that FKBP38 acts an upstream regulator of mTOR signaling pathway, which control the process of cell-growth, proliferation and differentiation. In order to explore the relationship between FKBP38 and mTOR in the Cashmere goat (Capra hircus) cells, a full-length cDNA was cloned (GenBank accession number JF714970) and expression patte...
متن کاملSilencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts.
FKBP38 (also known as FKBP8) is a unique member of the FK506-binding protein (FKBP) family, and its role is controversial because it acts as an upstream regulator of the mTOR signaling pathway, which controls cell growth, proliferation, and differentiation. This study aimed to explore the role of FKBP38 in the activation of mTOR signaling in Cashmere goat (Capra hircus) fetal fibroblasts. To co...
متن کاملDirect Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells
Ras homolog enriched in brain (Rheb) and FK506 binding protein 38 (FKBP38) are two important regulatory proteins in the mammalian target of rapamycin (mTOR) pathway. There are contradictory data on the interaction between Rheb and FKBP38 in human cells, but this association has not been examined in cashmere goat cells. To investigate the interaction between Rheb and FKBP38, we overexpressed goa...
متن کاملGrowth and viability of Liaoning Cashmere goat hair follicles during the annual hair follicle cycle.
Here, we studied hair follicle development of Liaoning Cashmere goats. Every month for 1 year, skin samples were collected from five 1.5-year-old female goats, and made into paraffin sections. A number of parameters were measured of primary and secondary hair follicles via microscopic observation including follicle depth, hair bulb width, dermis and epidermis thickness, changes in follicle acti...
متن کاملPost-Natal Skin Follicle Development in The Raieni Cashmere Goat
One hundred eighty (180) skin samples were taken from the mid-right side of 30 Raieni Cashmere goat male and female kids at 1 mo, 1.5 mo, 2 mo, 2.5 mo, 3 mo and 3.5 mo of age. Numbers of primary and secondary skin follicles were determined for each sample. Numbers of secondary follicles increased until 3 mo of age, but numbers of primary follicles did not change after birth of the kids. The ski...
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ژورنال
عنوان ژورنال: Journal of Applied Animal Research
سال: 2018
ISSN: 0971-2119,0974-1844
DOI: 10.1080/09712119.2018.1495643